The Moon possesses a clear dichotomy in geological processes between the nearside and farside hemispheres. The most pronounced expressions of this dichotomy are the strong concentration of radioactive heat sources on the nearside in a region known as the Procellarum KREEP Terrane (PKT) and the mare basaltic lava flows that erupted in or adjacent to this terrane. We model the thermochemical evolution of the Moon using a 3-D spherical thermochemical convection code in order to assess the consequences of a layer enriched in heat sources below the PKT on the Moon's global evolution. We find that in addition to localizing most of the melt production on the nearside, such an enriched concentration of heat sources in the PKT crust has an influence down to the core-mantle boundary and leaves a present-day temperature anomaly within the nearside mantle. Moderate gravitational and topographic anomalies that are predicted in the PKT, but not observed, may be masked either by crustal thinning or gravitational anomalies from dense material in the underlying mantle. Our models also predict crystallization of an inner core for sulfur concentrations less than 6 wt %.