Citizen / General public
Student / Future student
Public partner
Teacher / Pupil

MAMI – Medical Applications of Stable Isotopes

Start: 01/01/2022

National partnership

Coordinators : Frederic Moynier

Host institutions :

Related themes :
Earth System Science

Elements such as Cu and Zn play critical roles in normative brain function, and thus their dysregulation is intrinsically linked to neurodegenerative disorders (Bush, 2003). When the binding environment in the brain changes in response to disease, we have shown that upon accumulation and aggregation of Aβ aggregates, this change produces a related and measurable change (excursion) in the relative abundances of naturally occurring stable isotopes, e.g., Cu and Zn, in the affected regions (by isotope fractionation). We have confirmed the hypothesis in several mouse models of Alzheimer’s disease and, more importantly, we have now confirmed it in a small group of post-mortem human brain tissues. All of this work represents the application of geochemical methods to medical science.

In this project we are continuing these studies to validate these hypotheses is whether the excursions in Cu and Zn isotopic compositions of brain tissue during AD development (confirmed in post-mortem human brain tissue; (Moynier et al., 2020) will be recapitulated by changes in Cu and Zn isotopic compositions in blood fractions. We will also extend these studies to other elements such as K or Ca.

Translated with (free version)

Read more
Cosmochimie, astrophysique et géophysique expérimentale (CAGE)
Cosmochimie, astrophysique et géophysique expérimentale (CAGE)
L’équipe CAGE (Cosmochimie, Astrophysique et Géophysique expérimentale) regroupe des chercheurs et enseignants/chercheurs qui ont pour point commun d’...
Cosmochemistry, Astrophysics and Experimental Geophysics (CAGE)
Cosmochemistry, Astrophysics and Experimental Geophysics (CAGE)
The CAGE team (Cosmochemistry, Astrophysics, and Experimental Geophysics) brings together researchers and teachers with common research foci aimed at ...
Earth System Science
Earth System Science
Measuring, understanding and modelling the functioning of our planet's surface, also called the Critical Zone.