Mickael Tharaud
Content / Work
As a research engineer, I have the opportunity to make an active contribution to the design and implementation of innovative research projects linked to the challenges posed by current environmental and societal issues. Currently manager of 2 state-of-the-art inductively coupled plasma mass-spectrometers (one high-resolution and one time-of-flight ICP-MS), my research is particularly focused on the development of new methodologies for the detection, quantification and characterization of nanoparticles in environmental matrices (i.e. water, soils and organic materials) especially thanks to single-particle inductively coupled plasma time-of-flight mass spectrometry. spICP-ToF-MS is a technique used for elemental analysis of individual nanoparticles. It involves the injection of nanoparticles into an inductively coupled plasma, where they are vaporized and ionized, and the resulting ions are separated and analyzed based on their time-of-flight in a mass spectrometer, allowing for precise characterization of the elemental composition, number concentration and mass/size distribution of individual nanoparticles in a sample. Sample preparation as well as data examination are also addressed in my research activities allowing a more complete approach of the analytical procedure.Google Schoolar Researcher ID GitHub LinkedIn
Qualifications
- 2022. Data Science certification (LeWagon, France)
- 2021. PhD. in Earth and environmental Science (Université Paris Cité - IPGP, France)
- 2008. MSc. in environmental chemistry (Université de Limoges, France)
Experience
- 2023 – Pres. Research Engineer (IPGP - Université Paris Cité)
- 2018 - Pres. Technical manager of PARI
- 2011 - 2023. Engineer in analytical chemistry (IPGP - Université Paris Cité)
- 2009 - 2011. Engineer in geochemistry (IPGP - CNRS)
PhD supervision
- 2022 - 2025. M. Gelin (co-supervision 30%): The role of nanophase formation and transport in critical zone dynamics
- 2021 - 2024. F. Wang (co-supervison 50%): The cycle of nanoparticle within the critical zone
Teaching
- 2018 - Pres. Advanced plasma source Mass-Spectrometry (Doctoral school STEP'UP)
- 2015 - Pres. Inductively Coupled Plasma Mass-Spectrometry (Licence professionnelle in analytical chemistry)
Projects
PIREN Seine: transfers of nanoparticles to watercourses in drained agricultural basins
Characterising nanoparticles from agricultural catchments to better understand their origin and fate in the critical zone.
Post-FIRE pollutants mobilisation into surface water resources
This multi-faceted approach aims to fully understand the environmental consequences of wildfires and their impact on the contamination of water resour...
TOF-COL
The formation of nano-sized (between 1 nm and 1 µm) particles is one of the most under-constrained processes of soil formation, while their export by ...
Publications
Isambert Aude, Sivry Yann, Coural Sophie, Tharaud Mickaël, Benedetti Marc F., Carvallo Claire, Turcati Laure, Franke Christine, Macouin Mélina, Rousse Sonia. Cartographie de la pollution aux particules fines métalliques en zone urbaine. Le cas du Grand Paris de 2016 à aujourd’hui : apport des sciences participatives. 30 October 2023.
Lécuyer Thomas, Seguin Johanne, Balfourier Alice, Delagrange Marine, Bürckel Pierre, Lai-Kuen René, Mignon Virginie, Ducos Bertrand, Tharaud Michael, Saubaméa Bruno, Scherman Daniel, Mignet Nathalie, Gazeau Florence, Richard Cyrille. Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up. Nanoscale, Royal Society of Chemistry, 10 October 2022, 14. <10.1039/D2NR03546D>
Tharaud Mickaël, Schlatt Lukas, Shaw Phil, Benedetti Marc. Nanoparticle identification using single particle ICP-ToF-MS acquisition coupled to cluster analysis. From engineered to natural nanoparticles. Journal of Analytical Atomic Spectrometry, Royal Society of Chemistry, 07 October 2022, 37. <10.1039/d2ja00116k>
Amor Matthieu, Faivre Damien, Corvisier Jérôme, Tharaud Mickaël, Busigny Vincent, Komeili Arash, Guyot Francois. Defining Local Chemical Conditions in Magnetosomes of Magnetotactic Bacteria. Journal of Physical Chemistry B, American Chemical Society, 14 April 2022, 126. <10.1021/acs.jpcb.2c00752>
Tharaud Mickael. Vers une version 2.0 de la spICPMS pour mieux comprendre la biogéochimie des nanophases dans l'environnement.. 10 December 2021.
Vinck Robin, Karges Johannes, Tharaud Mickaël, Cariou Kevin, Gasser Gilles. Physical, Spectroscopic, and Biological Properties of Ruthenium and Osmium Photosensitizers Bearing Diversely Substituted 4,4'-di(styryl)-2,2'-bipyridine Ligands. Dalton Transactions, Royal Society of Chemistry, 21 September 2021. <10.1039/D1DT02083H>
Yeghicheyan Delphine, Grinberg Patricia, Alleman Laurent, Belhadj Moustafa, Causse Léa, Chmeleff Jérôme, Cordier Laure, Djouraev Irina, Dumoulin David, Dumont Jean, Freydier R., Mariot Hélène, Cloquet Christophe, Kumkrong Paramee, Malet Bruno, Jeandel Catherine, Marquet Aurélie, Riotte Jean, Tharaud Mickaël, Billon Gabriel, Trommetter Guillaume, Séby Fabienne, Guihou Abel, Deschamps Pierre, Mester Zoltan. Collaborative determination of trace element mass fractions and isotope ratios in AQUA-1 drinking water certified reference material. Analytical and Bioanalytical Chemistry, Springer Verlag, August 2021, 413. <10.1007/s00216-021-03456-8>
Phalyvong Karine, Sivry Yann, Pauwels Hélène, Gélabert Alexandre, Tharaud Mickael, Wille Guillaume, Bourrat Xavier, Ranville James F., Benedetti Marc F.. Assessing CeO2 and TiO2 Nanoparticle Concentrations in the Seine River and Its Tributaries Near Paris. Frontiers in Environmental Science, Frontiers, 11 February 2021, 8. <10.3389/fenvs.2020.549896>
Bolaños-Benítez Viviana, van Hullebusch Eric, Birck Jean-Louis, Garnier Jérémie, Lens Piet N.L., Tharaud Mickaël, Quantin Cécile, Sivry Yann. Chromium mobility in ultramafic areas affected by mining activities in Barro Alto massif, Brazil: An isotopic study. Chemical Geology, Elsevier, February 2021, 561. <10.1016/j.chemgeo.2020.120000>
Tharaud Mickael, Louvat Pascale, Benedetti Marc F.. Detection of nanoparticles by single-particle ICP-MS with complete transport efficiency through direct nebulization at few-microlitres-per-minute uptake rates. Analytical and Bioanalytical Chemistry, Springer Verlag, January 2021, 413. <10.1007/s00216-020-03048-y>
Karges Johannes, Tharaud Mickaël, Gasser Gilles. Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers. Journal of Medicinal Chemistry, American Chemical Society, 2021. <10.1021/acs.jmedchem.0c02006>
Wang Jialan, Alasonati Enrica, Tharaud Mickael, Gelabert Alexandre, Fisicaro Paola, Benedetti Marc F.. Flow and fate of silver nanoparticles in small French catchments under different land-uses: The first one-year study. Water Research, IWA Publishing/Elsevier, June 2020, 176. <10.1016/j.watres.2020.115722>
Notaro Anna, Frei Angelo, Rubbiani Riccardo, Jakubaszek Marta, Basu Uttara, Koch Severin, Mari Cristina, Dotou Mazzarine, Blacque Olivier, Gouyon Jeremie, Bedioui Fethi, Rotthowe Nils, Winter Rainer F, Goud Bruno, Ferrari Stefano, Tharaud Mickaël, Rezácová Martina, Humajová Jana, Tomšík Pavel, Gasser Gilles. A Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies. Journal of Medicinal Chemistry, American Chemical Society, 22 April 2020. <10.1021/acs.jmedchem.0c00431>
Munteanu Alexandra-Cristina, Notaro Anna, Jakubaszek Marta, Cowell Joseph, Tharaud Mickaël, Goud Bruno, Uivarosi Valentina, Gasser Gilles. Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands. Inorganic Chemistry, American Chemical Society, 19 March 2020. <10.1021/acs.inorgchem.9b03562>
Notaro Anna, Jakubaszek Marta, Koch Severin, Rubbiani Riccardo, Dömötör Orsolya, Enyedy Eva A, Dotou Mazzarine, Bedioui Fethi, Tharaud Mickaël, Goud Bruno, Ferrari Stefano, Alessio Enzo, Gasser Gilles. A maltol‐containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent. Chemistry - A European Journal, Wiley-VCH Verlag, 17 February 2020. <10.1002/chem.201904877>
Notaro Anna, Jakubaszek Marta, Rotthowe Nils, Maschietto Federica, Vinck Robin, Felder Patrick S, Goud Bruno, Tharaud Mickaël, Ciofini Ilaria, Bedioui Fethi, Winter Rainer, Gasser Gilles. Increasing the Cytotoxicity of Ru(II) Polypyridyl Complexes by tuning the Electronic Structure of Dioxo Ligands. Journal of the American Chemical Society, American Chemical Society, 2020. <10.1021/jacs.9b12464>
Karges Johannes, Yempala Thirumal, Tharaud Mickaël, Gibson Dan, Gasser Gilles. A Multiaction and Multitarget Ru(II)-Pt(IV) Conjugate Combining Cancer Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020. <10.1002/anie.201916400>
Soliman Nancy, Mckenzie Luke, Karges Johannes, Bertrand Emilie, Tharaud Mickaël, Jakubaszek Marta, Guérineau Vincent, Goud Bruno, Hollenstein Marcel, Gasser Gilles, Thomas Christophe M. Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer. Chemical Science, The Royal Society of Chemistry, 2020, 11. <10.1039/c9sc05976h>
Louvat Pascale, Tharaud Mickaël, Buisson Matthieu, Rollion-Bard Claire, Benedetti Marc. μ-dDIHEN: a new micro-flow liquid sample introduction system for direct injection nebulization in ICP-MS. Journal of Analytical Atomic Spectrometry, Royal Society of Chemistry, 31 July 2019, 34. <10.1039/c9ja00146h>
Bolaños-Benítez Viviana, van Hullebusch Eric, Garnier Jérémie, Quantin Cecile, Tharaud Mickaël, Lens Piet N.L., Sivry Yann. Assessing chromium mobility in natural surface waters: Colloidal contribution to the isotopically exchangeable pool of chromium (E w Cr value). Applied Geochemistry, Elsevier, May 2018, 92. <10.1016/j.apgeochem.2018.02.007>